Tuesday, December 29, 2009

Global Antibiotic Resistance Scenario-By Dr. A.J. Tamhankar

A study from Ireland in the journal “Microbiology” says that Disinfectants “teach” bacteria to become resistant to antibiotics. The study exposed Pseudomonas- a common hospital bacterium- to non-lethal concentrations of some disinfectant and found that it enhanced their efflux pump mechanisms, making them less sensitive to not only the disinfectant, but also to ciprofloxacin.
Nature has published an article which says that
`Sequencing neglected microbes could accelerate the discovery of new protein families and biological traits`. It is quite possible that this may even give clues for development of new antibiotics.
An article in MSNBC brings out that `Drug-resistant infections lurk in the meat we eat and Animals routinely fed antibiotics harbor virulent germs that jump to people.
Further from US --The following four articles in the journal `Emerging infectious diseases` indicate the
serious threat of transfer of antibiotic resistance from animals to humans - Public Health Threat of New, Reemerging, and Neglected Zoonoses in the Industrialized World;Ceftiofur Resistance in Salmonella enterica Serovar Heidelberg from Chicken Meat and Humans, Canada;Methicillin-Resistant and -Susceptible Staphylococcus aureus Infections in Dogs;Food Reservoir for Escherichia coli Causing Urinary Tract Infections. Now the question is--- will the US Congress ban the growth promoter use of antibiotics in animals?
Bacteria of the genus Salmonella cause most food-borne illnesses. The ingestion by humans occurs mainly via contaminated egg dishes such as mayonnaise or raw milk products as well as meat or sausages. Infections with Salmonella lead to severe diarrhoea and fever, particularly in patients harbouring a compromised immune system. Researchers from the Helmholtz Centre for Infection Research in Braunschweig, Germany, say that "Based on our data, the
molecular mechanism of infection employed by Salmonella has to be revised," The results have now been published in the of the scientific journal Cellular Microbiology.
It has become harder for the Chinese to self-medicate.
The Chinese government is heavily coming down on self prescribed antibiotics .
Scientists at Binghamton University, State University of New York, have identified
three key regulators required for the formation and development of bacterial biofilms. The discovery could lead to new ways of treating chronic infections.
Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis is successful.
An interesting story about bacteria has emerged which tells about
Electricity-Producing Bacteria Near Energy Sources
It is proposed that Fungal footage may foster foresight into plant, animal disease (w/ Video)
An Enzyme has been discovered that
disturbs the communication processes between bacteria.
Anti-infection agents from Nanoemulsions - Nanoemulsions are superfine mixtures of soybean oil and water, stabilized by surfactants and blended at very high speeds so that the resulting droplets are less than 400 nanometers in diameter. Nanoemulsion droplets fuse with a microbe's outer membrane, disrupt the membrane and kill the organism.

1 comment:

Sayantan Banerjee said...

Sir the Phase 2 trial for Eritoran tetrasodium can not be called successful. The p value of the highest dose of eritoran used was not significant to be distinct than from that of placebo.
The articles may please be reviewed and the comment that Eritoran is successful may please be edited.
Thanks and regards
Sayantan Banerjee
drsayantan@gmail.com
MD student, MAMC, Delhi

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